IN VITRO STUDY OF INTERACTIONS BETWEEN I.V. ANAESTHETICS AND NEUROMUSCULAR BLOCKING AGENTS
نویسندگان
چکیده
منابع مشابه
In vitro study of interactions between i.v. anaesthetics and neuromuscular blocking agents.
The interactions of four anaesthetic drugs (ketamine, propanidid, Althesin and methohexitone) with two neuromuscular blocking agents (suxamethonium and pancuronium) have been investigated. On the isolated rat phrenic nerve-diaphragm preparation, all the anaesthetic drugs examined potentiated suxamethonium more than they potentiated pancuronium. The anticholinesterase agent, ecothiopate, had no ...
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In cats lightly anaesthetized with chloralose, ventilation with 75 per cent nitrous oxide did not affect arterial blood pressure, heart rate or the responses of gastrocnemius muscles to indirect stimulation; blockade by tubocurarine and gallamine was significantly enhanced but that by suxamethonium was almost unchanged. Ventilation with approximately 0.5 per cent halothane caused hypotension an...
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15 صفحه اولNeuromuscular Blocking Agents
• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...
متن کاملMechanisms of the synergistic interactions between organic calcium channel antagonists and various neuromuscular blocking agents.
The effects of Mn2+, neomycin and four organic Ca2(+)-channel antagonists (OCA): nicardipine, nifedipine, diltiazem and verapamil on the neuromuscular blocking activities of tubocurarine, succinylcholine (SCh), decamethonium and neomycin were studied in isolated mouse phrenic nerve-diaphragm preparations. The effective concentration of SCh for 50% inhibition (IC50) of single indirect twitch res...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1977
ISSN: 0007-0912
DOI: 10.1093/bja/49.8.765